Johns Hopkins DELTA Center Symposium on Alcohol-associated Hepatitis: Pathogenesis, Treatment, and Challenges.

JHUDC

This two-day symposium will gather leading experts from around the world to discuss recent advancements in the pathogenesis and treatment of alcohol-associated hepatitis. In addition to our keynote speakers, Drs. George Koob and Ramon Bataller, over 20 distinguished speakers will present their latest research. The event will also feature presentations from selected young investigators representing more than 30 laboratories and institutions across the U.S. Poster presentations are open to all registered attendees, including young investigators, postdoctoral fellows, and trainees. Abstract submissions (up to 250 words) for oral or poster presentations are welcome, with a submission and registration deadline of October 15, 2024. After registering, abstracts can be emailed to deltalivertransplant@jhmi.edu for review. There are two options for registration. Option 1 includes in-person attendance along with lunch and dinner Friday and lunch on Saturday. Option 2 includes in-person attendance only. 

The symposium will be held at the Johns Hopkins Bloomberg Conference Center at 555 Pennsylvania Avenue, NW in Washington, D.C.

 

Organizers:                                                                                          

Zhaoli Sun MD, Ph.D., Johns Hopkins                                          

Dan Warren Ph.D., Johns Hopkins                                                

Wen-Xing Ding, Ph.D., UKMC                                                            

 

Chairpersons:              

Andrew Cameron, MD, PhD, Johns Hopkins 

Bin Gao, MD, PhD, NIAAA 

Zhaoli Sun, MD, PhD, Johns Hopkins 

 

Keynote Speakers:       

George Koob, PhD, NIAAA

Ramon Bataller, MD, PhD, Hospital Clinic of Barcelona, Spain

 

Speakers:

Juan Pablo (JP) Arab, MD, Virginia Commonwealth University School of Medicine

Andrew Cameron MD, PhD, Johns Hopkins

Carol Casey PhD, University of Nebraska

Victor Chen MD, Johns Hopkins

Wen-Xing Ding, PhD, University of Kansas Medical Center

Bin Gao, MD, PhD, NIAAA

Leila Gobejishvili, PhD, University of Louisville

Yasuko Iwakiri, PhD, Yale School of Medicine

Cynthia Ju, PhD, University of Texas Health Science Center at Houston

Auinash Kalsotra, PhD, University of Illinois

Patrick Kamath, MD, Mayo Clinic

Suthat Liangsipukul MD, MPH, Indiana university

Wajahat Mehal, MD, DPhil, Yale University School of Medicine

Mack Mitchel, MD, UT Southwestern

Laura Nagy, PhD, Cleveland Clinic

Michael Nathanson, MD, PhD, Yale School of Medicine

Pal Pacher, PhD, NIAAA

Bernd Schnabl, MD, UCSD

Ekihiro Seki MD, PhD, Cedar Sinai Medical center

Peter Starkel, MD, PhD, Clinic at the Catholic University of Louvain, Belgium

Zhaoli Sun MD, PhD, Johns Hopkins

Gyongyi Szabo, MD, PhD, Beth Israel Deaconess Medical Center/Harvard

Hidekazu Tsukamoto, PhD, USC

Chris Umbricht MD, PhD, Johns Hopkins

Hua Wang, MD, PhD, Anhui Medical University, China

Xiaoming Yin, MD, PhD, Tulane University of Louisiana

Mengwei Zang, MD, PhD, UT Health San Antonio

Huiping Zhou Ph.D., Virginia Commonwealth University 

Heng Zhu, PhD, Johns Hopkins

Additional Travel and Location Information

Scientific Program

Friday, November 1  

8:50 - 9:00 am 

Opening Remarks

Andrew Cameron, MD, PhD 

Chair, Department of Surgery 

Johns Hopkins University School of Medicine 

 

Bin Gao, MD, PhD 

Deputy Scientific Director 

NIAAA/NIH

 

9:00 - 9:30 am 

Keynote Presentation   

Chair: Anna Mae Diehl, MD (Duke University)

 

“Alcohol-associated hepatitis: current trends and novel targets for therapy”

Ramon Bataller, MD, PhD, Director, Hospital Clinic of Barcelona, Spain

 

9:30 – 11:10 am

Session 1: Alcohol-associated Hepatitis: Pathogenesis I

Chairs: James P. Hamilton, MD (Johns Hopkins) and Bernd Schnabl, MD (UCSD)

 

9:30 – 9:50 am   “Characterization of liver inflammation in severe alcohol-associated hepatitis”

                                Bin Gao, MD, PhD, Deputy Scientific Director, NIAAA

 

9:50 – 10:10 am   "Uncovering the role of neutrophils in alcohol-associated hepatitis and in MetALD” 

                                 Gyongyi Szabo, MD, PhD, Professor and Dean for Academic Affairs, Beth Israel Deaconess Medical Center/Harvard

 

10:10 – 10:30 am  “A new type of interaction between neutrophils and hepatocytes in alcohol-associated hepatitis

                                   Michael Nathanson, MD, PhD, Professor of Medicine, Yale School of Medicine 

 

10:30 – 10:45 am Break

 

10:45 – 11:45 pm

Session 2: Alcohol-associated Hepatitis: Pathogenesis II

Chairs: Carol Casey, PhD (University of Nebraska) and Hidekazu Tsukamoto, PhD (USC)

 

10:45 – 11:05 am  “Increased expression of cyclic AMP-specific phosphodiesterase 4 promotes the development of alcohol-associated hepatitis: clinical and preclinical evidence”

                                   Leila Gobejishvili, PhD, Associate Professor of Medicine, University of Louisville

 

11:05 – 11:25 am   “Bile Acids and Sphingolipids in Alcoholic Liver Injury.”

                                  Huiping Zhou PhD, Professor of Microbiology and Immunology, Virginia Commonwealth University

 

11:25 – 11:45 am   “Endothelial Dysfunction in Alcohol-Associated Liver Disease: Mechanisms and Implications”

                                  Yasuko Iwakiri, PhD, Professor of Medicine, Yale School of Medicine

 

11:45 – 12:40 pm

Session 3: Alcohol-associated Hepatitis: Pathogenesis III

Chairs: Laura Nagy, PhD (Cleveland Clinic) and Xiaoming Yin, MD, PhD (Tulane University)

 

11:45 – 12:05 pm   “Role of miRNAs in Liver Regeneration and Prognostic Outcomes in Alcohol-Associated Hepatitis"

                                   Suthat Liangpunsakul, MD, MPH, Professor of Medicine, Indiana University

 

12:05 – 12:25 pm   “Dysregulated RNA splicing promotes regeneration failure in severe alcoholic hepatitis” 

                                   Auinash Kalsotra, PhD, Professor of Biochemistry, University of Illinois

 

12:25 – 12:40 pm   “DNA methylation signatures of Severe Alcohol-associated Hepatitis and its inflammatory response”

                                    Chris Umbricht, MD, PhD, Associate Professor of Surgery and Oncology, Johns Hopkins

 

12:40 – 1:00 pm     Lunch (lunch box)

 

1:00 – 1:30 pm

Keynote Presentation

Chair: Andrew Cameron, MD, PhD (Johns Hopkins)

 

TBD

George Koob, PhD, Director, NIAAA

 

1:30 – 2:50pm

Session 4: Alcohol-associated Hepatitis: Pathogenesis IV

Chairs: Gary Murray, PhD (NIAAA) and Wen-Xing Ding, PhD (UKMC) 

 

1:30 – 1:50 pm    “Alcohol and Lipid and Protein Trafficking Don’t Mix”

                                Carol Casey, PhD, Professor of Gastroenterology and Hepatology, University of Nebraska

 

1:50 – 2:10 pm   “Role of NOX2 in alcohol-associated liver injury”

                               Cynthia Ju, PhD, Professor of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center at Houston

 

2:10 – 2:30 pm   “Lrat+Fbln2+ hepatic stellate cells in MetALD hepatitis and liver cancer”

                               Hidekazu Tsukamoto, PhD, Professor of Pathology, USC

 

2:30 – 2:50 pm   “Cholestasis can trigger alcohol-associated hepatitis in mice"

                                Xiao-Ming Yin, MD, PhD, Professor and Chair, Department of Pathology and Laboratory Medicine, Tulane University of Louisiana

 

2: 50 – 3:10 pm   Break

 

3:10 – 4:50 pm

Session 5: Alcohol-associated Hepatitis: Pathogenesis V

ChairsYasuko Iwakiri, PhD (Yale University) and Ping Zhang, MD, PhD (NEOMED)

 

3:10 – 3:30 pm   “Mitochondrial maladaptation in Alcohol-Associated Liver Disease”

                               Wen-Xing Ding, PhD, Professor of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center

 

3:30 – 3:50 pm   "Stressed hepatocytes sustain alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2

                                Hua Wang, MD, PhD, Anhui Medical University, China

 

3:50 – 4:10 pm   “Modeling alcoholic-associated liver disease using liver-on-a-chip platform”.

                                Ekihiro Seki MD, PhD, Professor Medicine and Biomedical Sciences, Cedar Sinai Medical Center

 

4:10 – 4:30 pm   “Liver Disease Beyond the Organ: Cardiovascular, Renal, and Pulmonary Implications”

                                Pal Pacher, MD, PhD, Senior Investigator, NIAAA

 

4:30 – 4:50 pm   “FGF21: New Insights into the Therapeutic Impact on Alcohol-Associated Liver Disease"

                                Mengwei Zang, MD, PhD, Professor of Molecular Medicine, UT Health San Antonio

 

4:50 – 5:30 pm Break 

 

5:30 – 8:30 pm Dinner, Social Events and Posters

 

Saturday, November 2          

8:30 – 10:10 am 

Session 6: Alcohol-associated Hepatitis: Pathogenesis VI

Chairs: Ramon Bataller, MD, PhD (Hospital Clinic of Barcelona) and Ahmet Gurakar, MD (Johns Hopkins)

 

8:30 - 8:50 am   “Small bugs, big changes: a microbiota-centered view of alcohol-associated hepatitis”

                               Bernd Schnabl, MD, Professor of Medicine, UCSD

 

8:50 – 9:10 am   "Alterations of the intestinal CD8+ T resident memory cells pool in AUD patients with alcohol-associated liver disease 

                               Peter Starkel, MD, PhD, Professor of Medicine, Clinic at the Catholic University of Louvain, Belgium

 

9:10 – 9:30 am   “Complement in Alcohol-associated liver disease”

                               Laura Nagy, PhD, Professor of Medicine, Cleveland Clinic 

 

9:30 - 9:50 am    "Cross-reactive Intrahepatic Antibodies in Severe Alcohol-associated Hepatitis 

                                Heng Zhu, PhD, Professor of Pharmacology and Molecular Science, Johns Hopkins

 

9:50 - 10:10 am   “Direct activation of hepatic stellate cells by ethanol”

                                 Wajahat Mehal, MD, DPhil, Professor of Medicine, Yale School of Medicine

 

10:10 – 10:30 am   Break

 

10:30 – 11:50 am

Session 7: Alcohol-associated Hepatitis: Treatment

Chairs: Suthat Liangpunsakul, MD, MPH (Indiana University) and Russell Wesson, MD (Johns Hopkins)

 

10:30 – 10:50 am   “Results of Recent Clinical Trials in Severe Alcohol-associated Hepatitis”

                                    Mack Mitchel, MD, Professor of Internal Medicine and Vice President for Medical Affairs, UT Southwestern

 

10:50 – 11:10 am   “ALD&AH: from predictive models to population health"

                                   Juan Pablo (JP) Arab, MD, Director of Alcohol Sciences Institute for Liver Disease and Metabolic Health, Virginia Commonwealth University School of Medicine

 

11:10 – 11:30  am   “Nutrition therapy for alcohol-associated liver disease”

                                    Craig McClain MD, Professor of Medicine, University of Louisville

 

11:30 – 12:30 pm

Session 8: Early Liver Transplantation

Chairs: Mack Mitchel, MD (UT Southwestern) and Anna Mae Diehl, MD (Duke)

 

11:30 – 11:50 am   “Transplant for AUD: Lessons Learned and Next Steps”

                                   Andrew Cameron, MD, PhD, Professor and Chair of Surgery, Johns Hopkins

 

11:50 – 12:10 pm   "The Flip Side of the Coin: Treating Alcohol Use Disorder in the Presence of Concurrent Liver Disease"

                                   Po-Hung (Victor) Chen, MD, PhD, Assistant Professor of Medicine, Johns Hopkins

 

12:10 – 12:30 pm   “ELT for AUD: Impact of Systemic Alcohol Environment on Liver Allograft”

                                   Zhaoli Sun, MD, PhD, Professor of Surgery and Pharmacology, Johns Hopkins

 

12:30 – 1:30 pm    Lunch and Posters

 

1: 30 – 3:30 pm

Session 9: Short talks

 

1:30 – 2:30 pm   Session A

Chairs: Robert Anders, MD, PhD (Johns Hopkins) and Po-Hung (Victor) Chen, MD, PhD (Johns Hopkins)

Speakers: TBD

 

2:30 – 3:30 pm Session B

Chairs: Dan Warren, PhD (Johns Hopkins) and Huiping Zhou, PhD (Virginia Commonwealth University) 

Speakers: TBD

 

3: 30 – 4:00 pm 

Session 10: Panel Discussion - Future Research

Chairs: Bin Gao, MD, PhD (NIAAA) and Zhaoli Sun, MD, PhD (Johns Hopkins)

 

Panelists: Ramon Bataller, MD, Andrew Cameron, MD, PhD, Carol Casey, PhD, Anna Mae Diehl, MD, Wen-Xing Ding, PhD, Suthat Liangpunsakul, MD, Mack Mitchel, MD, Laura Nagy, PhD, Bernd Schnabl, MD, Gyongyi Szabo, MD, and Hidekazu Tsukamoto, PhD.

 

Registration Information

Please click the orange box labeled "Continue as Guest" and follow the prompts to complete the registration process. After registering, you may e-mail your abstract submission to deltalivertransplant@jhmi.edu for review. 

 Event Date
Starts:
Friday, November 1, 2024
9:00am EDT

Ends:
Saturday, November 2, 2024
4:00pm EDT

 Location
The Johns Hopkins University Bloomberg Center

555 Pennsylvania Avenue NW
Washington, DC 20001

 Contact
JHU Surgery
Daniel Warren
410-502-0122
warren@jhmi.edu

Status message

Sorry, this form is closed to new submissions.