Friday, November 1
8:50 - 9:00 am
Opening Remarks
Andrew Cameron, MD, PhD
Chair, Department of Surgery
Johns Hopkins University School of Medicine
Bin Gao, MD, PhD
Deputy Scientific Director
NIAAA/NIH
9:00 - 9:30 am
Keynote Presentation
Chair: Anna Mae Diehl, MD (Duke University)
“Alcohol-associated hepatitis: current trends and novel targets for therapy”
Ramon Bataller, MD, PhD, Director, Hospital Clinic of Barcelona, Spain
9:30 – 11:10 am
Session 1: Alcohol-associated Hepatitis: Pathogenesis I
Chairs: James P. Hamilton, MD (Johns Hopkins) and Bernd Schnabl, MD (UCSD)
9:30 – 9:50 am “Characterization of liver inflammation in severe alcohol-associated hepatitis”
Bin Gao, MD, PhD, Deputy Scientific Director, NIAAA
9:50 – 10:10 am "Uncovering the role of neutrophils in alcohol-associated hepatitis and in MetALD”
Gyongyi Szabo, MD, PhD, Professor and Dean for Academic Affairs, Beth Israel Deaconess Medical Center/Harvard
10:10 – 10:30 am “A new type of interaction between neutrophils and hepatocytes in alcohol-associated hepatitis”
Michael Nathanson, MD, PhD, Professor of Medicine, Yale School of Medicine
10:30 – 10:45 am Break
10:45 – 11:45 pm
Session 2: Alcohol-associated Hepatitis: Pathogenesis II
Chairs: Carol Casey, PhD (University of Nebraska) and Hidekazu Tsukamoto, PhD (USC)
10:45 – 11:05 am “Increased expression of cyclic AMP-specific phosphodiesterase 4 promotes the development of alcohol-associated hepatitis: clinical and preclinical evidence”
Leila Gobejishvili, PhD, Associate Professor of Medicine, University of Louisville
11:05 – 11:25 am “Bile Acids and Sphingolipids in Alcoholic Liver Injury.”
Huiping Zhou PhD, Professor of Microbiology and Immunology, Virginia Commonwealth University
11:25 – 11:45 am “Endothelial Dysfunction in Alcohol-Associated Liver Disease: Mechanisms and Implications”
Yasuko Iwakiri, PhD, Professor of Medicine, Yale School of Medicine
11:45 – 12:40 pm
Session 3: Alcohol-associated Hepatitis: Pathogenesis III
Chairs: Laura Nagy, PhD (Cleveland Clinic) and Xiaoming Yin, MD, PhD (Tulane University)
11:45 – 12:05 pm “Role of miRNAs in Liver Regeneration and Prognostic Outcomes in Alcohol-Associated Hepatitis"
Suthat Liangpunsakul, MD, MPH, Professor of Medicine, Indiana University
12:05 – 12:25 pm “Dysregulated RNA splicing promotes regeneration failure in severe alcoholic hepatitis”
Auinash Kalsotra, PhD, Professor of Biochemistry, University of Illinois
12:25 – 12:40 pm “DNA methylation signatures of Severe Alcohol-associated Hepatitis and its inflammatory response”
Chris Umbricht, MD, PhD, Associate Professor of Surgery and Oncology, Johns Hopkins
12:40 – 1:00 pm Lunch (lunch box)
1:00 – 1:30 pm
Keynote Presentation
Chair: Andrew Cameron, MD, PhD (Johns Hopkins)
TBD
George Koob, PhD, Director, NIAAA
1:30 – 2:50pm
Session 4: Alcohol-associated Hepatitis: Pathogenesis IV
Chairs: Gary Murray, PhD (NIAAA) and Wen-Xing Ding, PhD (UKMC)
1:30 – 1:50 pm “Alcohol and Lipid and Protein Trafficking Don’t Mix”
Carol Casey, PhD, Professor of Gastroenterology and Hepatology, University of Nebraska
1:50 – 2:10 pm “Role of NOX2 in alcohol-associated liver injury”
Cynthia Ju, PhD, Professor of Anesthesiology, Critical Care and Pain Medicine, University of Texas Health Science Center at Houston
2:10 – 2:30 pm “Lrat+Fbln2+ hepatic stellate cells in MetALD hepatitis and liver cancer”
Hidekazu Tsukamoto, PhD, Professor of Pathology, USC
2:30 – 2:50 pm “Cholestasis can trigger alcohol-associated hepatitis in mice"
Xiao-Ming Yin, MD, PhD, Professor and Chair, Department of Pathology and Laboratory Medicine, Tulane University of Louisiana
2: 50 – 3:10 pm Break
3:10 – 4:50 pm
Session 5: Alcohol-associated Hepatitis: Pathogenesis V
Chairs: Yasuko Iwakiri, PhD (Yale University) and Ping Zhang, MD, PhD (NEOMED)
3:10 – 3:30 pm “Mitochondrial maladaptation in Alcohol-Associated Liver Disease”
Wen-Xing Ding, PhD, Professor of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center
3:30 – 3:50 pm "Stressed hepatocytes sustain alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2
Hua Wang, MD, PhD, Anhui Medical University, China
3:50 – 4:10 pm “Modeling alcoholic-associated liver disease using liver-on-a-chip platform”.
Ekihiro Seki MD, PhD, Professor Medicine and Biomedical Sciences, Cedar Sinai Medical Center
4:10 – 4:30 pm “Liver Disease Beyond the Organ: Cardiovascular, Renal, and Pulmonary Implications”
Pal Pacher, MD, PhD, Senior Investigator, NIAAA
4:30 – 4:50 pm “FGF21: New Insights into the Therapeutic Impact on Alcohol-Associated Liver Disease"
Mengwei Zang, MD, PhD, Professor of Molecular Medicine, UT Health San Antonio
4:50 – 5:30 pm Break
5:30 – 8:30 pm Dinner, Social Events and Posters
Saturday, November 2
8:30 – 10:10 am
Session 6: Alcohol-associated Hepatitis: Pathogenesis VI
Chairs: Ramon Bataller, MD, PhD (Hospital Clinic of Barcelona) and Ahmet Gurakar, MD (Johns Hopkins)
8:30 - 8:50 am “Small bugs, big changes: a microbiota-centered view of alcohol-associated hepatitis”
Bernd Schnabl, MD, Professor of Medicine, UCSD
8:50 – 9:10 am "Alterations of the intestinal CD8+ T resident memory cells pool in AUD patients with alcohol-associated liver disease
Peter Starkel, MD, PhD, Professor of Medicine, Clinic at the Catholic University of Louvain, Belgium
9:10 – 9:30 am “Complement in Alcohol-associated liver disease”
Laura Nagy, PhD, Professor of Medicine, Cleveland Clinic
9:30 - 9:50 am "Cross-reactive Intrahepatic Antibodies in Severe Alcohol-associated Hepatitis
Heng Zhu, PhD, Professor of Pharmacology and Molecular Science, Johns Hopkins
9:50 - 10:10 am “Direct activation of hepatic stellate cells by ethanol”
Wajahat Mehal, MD, DPhil, Professor of Medicine, Yale School of Medicine
10:10 – 10:30 am Break
10:30 – 11:50 am
Session 7: Alcohol-associated Hepatitis: Treatment
Chairs: Suthat Liangpunsakul, MD, MPH (Indiana University) and Russell Wesson, MD (Johns Hopkins)
10:30 – 10:50 am “Results of Recent Clinical Trials in Severe Alcohol-associated Hepatitis”
Mack Mitchel, MD, Professor of Internal Medicine and Vice President for Medical Affairs, UT Southwestern
10:50 – 11:10 am “ALD&AH: from predictive models to population health"
Juan Pablo (JP) Arab, MD, Director of Alcohol Sciences Institute for Liver Disease and Metabolic Health, Virginia Commonwealth University School of Medicine
11:10 – 11:30 am “Nutrition therapy for alcohol-associated liver disease”
Craig McClain MD, Professor of Medicine, University of Louisville
11:30 – 12:30 pm
Session 8: Early Liver Transplantation
Chairs: Mack Mitchel, MD (UT Southwestern) and Anna Mae Diehl, MD (Duke)
11:30 – 11:50 am “Transplant for AUD: Lessons Learned and Next Steps”
Andrew Cameron, MD, PhD, Professor and Chair of Surgery, Johns Hopkins
11:50 – 12:10 pm "The Flip Side of the Coin: Treating Alcohol Use Disorder in the Presence of Concurrent Liver Disease"
Po-Hung (Victor) Chen, MD, PhD, Assistant Professor of Medicine, Johns Hopkins
12:10 – 12:30 pm “ELT for AUD: Impact of Systemic Alcohol Environment on Liver Allograft”
Zhaoli Sun, MD, PhD, Professor of Surgery and Pharmacology, Johns Hopkins
12:30 – 1:30 pm Lunch and Posters
1: 30 – 3:30 pm
Session 9: Short talks
1:30 – 2:30 pm Session A
Chairs: Robert Anders, MD, PhD (Johns Hopkins) and Po-Hung (Victor) Chen, MD, PhD (Johns Hopkins)
Speakers: TBD
2:30 – 3:30 pm Session B
Chairs: Dan Warren, PhD (Johns Hopkins) and Huiping Zhou, PhD (Virginia Commonwealth University)
Speakers: TBD
3: 30 – 4:00 pm
Session 10: Panel Discussion - Future Research
Chairs: Bin Gao, MD, PhD (NIAAA) and Zhaoli Sun, MD, PhD (Johns Hopkins)
Panelists: Ramon Bataller, MD, Andrew Cameron, MD, PhD, Carol Casey, PhD, Anna Mae Diehl, MD, Wen-Xing Ding, PhD, Suthat Liangpunsakul, MD, Mack Mitchel, MD, Laura Nagy, PhD, Bernd Schnabl, MD, Gyongyi Szabo, MD, and Hidekazu Tsukamoto, PhD.
